A chronological tour of the work behind the publications — the questions, the methods, and what each effort produced. For the formal record see Research; for the software, see Tools.
Open-source browser tools for drug & genomics analysis
Designed and shipped a family of free, client-side tools — DrugInteract, enrichlite, and drugtargets — that put drug-interaction lookup, gene-set enrichment, and drug-target exploration in the browser, with no backend and no data collection.
Preterm brain & cerebellar development
Multi-omics (RNA-seq, metabolomics, genomics) plus automated behavior analysis (DeepLabCut, B-SOiD, Erasmus Ladder) to quantify how preterm birth, NEC, and early-life interventions reshape neurodevelopment in mouse models and human data.
MyVivarium — open-source vivarium management
Co-developed a cloud-based, affordable platform for research animal colony management with QR-code cage cards and real-time IoT environmental sensing. Released open-source and published in Computational and Structural Biotechnology Journal.
Neuropathway modeling & nutraceutical–cancer therapy
Built a MATLAB computational-biology model for neuropathway analysis, and analyzed cancer genomics to design a nutraceutical combination for enhancing cancer therapy — resulting in a publication and a granted patent.
BEAT AML — computational drug-response prediction
Developed and validated protein-network and pathway models predicting AML response to BET, CDK4/6, IDH, and venetoclax-based regimens, benchmarked against ex-vivo drug-sensitivity data — contributing to a leukemia-genomics publication and multiple ASH abstracts.
Autoimmune disease models & cancer genomics database
Built molecular and cell-signaling models (TNF, interleukin, metabolism) and a comprehensive 8-cell-type autoimmune disease model validated against in-vivo data, plus a genomics database spanning 500+ cancer cell lines with TCGA and MSK datasets. Yielded multiple publications and patents in drug repurposing.
Inflammation & innate-immune signaling models
Systems-biology and in-silico modeling of oral inflammatory responses and defensin/chemokine signaling (with the Brogden lab and collaborators), and anti-inflammatory mechanism studies — contributing to several peer-reviewed publications.