Articles

Long-form writing on computational biology and the tools behind the research

Published articles

Over-representation analysis: what the numbers mean

What a gene-set enrichment result says and does not say: the three inputs, the test with worked numbers, multiple-testing correction, why GO, Reactome, and Hallmark disagree, and how to run it in the browser.

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Drug Repositioning Through Computational Modeling

How computational modeling and network-based methods find new uses for existing drugs — from cancer combinations to inflammatory disease.

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Digital twins in medicine, with a leukemia example

What a digital twin is, with examples from cardiology, diabetes, and immunology, and a worked example: a pathway model built from each of 100 AML genomes, a BET inhibitor simulated in it, and the result read as four quadrants.

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MyVivarium: Streamlining Lab Animal Colony Management

An open-source, cloud-based application for managing research animal colonies with IoT-based environmental monitoring. Published in Computational and Structural Biotechnology Journal.

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