Controls
Pathway parameters
Strength of the upstream input driving the cascade.
Active ERK inhibits the top of the cascade. Lower Ki = stronger negative feedback.
Drug
Reduces MEK's ability to phosphorylate ERK (e.g. a trametinib-like inhibitor).
Simulation
Time course
Response curve
Model equations & method
Integrated with a fixed-step 4th-order Runge–Kutta scheme. Concentrations are conserved by construction; species are held non-negative.
These are canonical, illustrative models from the systems-biology literature, using published parameter sets. They demonstrate qualitative behaviour (ultrasensitivity, feedback oscillations, emergent drug response) — they are not calibrated to any specific cell line or patient and are for educational use only.