8. Genes: names, cancer roles and literature¶
Page 8 of 9. previous: 7. Gene clusters and pathway flow | index | next: 9. Conclusions
The previous pages name genes by symbol. This page says what each gene is, whether it is a known cancer gene, what the literature says about it in medulloblastoma, and which signalling pathways it belongs to. It then reads every concordant change against that knowledge.
Sources, all public. Full names and the NCBI gene summary come from MyGene.info. Oncogene and tumour suppressor status comes from two curated lists: the OncoKB cancer gene list (gene type: oncogene, tumour suppressor, both, or neither) and the COSMIC Cancer Gene Census "role in cancer", read through the Open Targets Platform together with the COSMIC cancer hallmarks. Pathway membership is Reactome, also through Open Targets. Literature is a PubMed count of papers that mention the gene together with medulloblastoma in title or abstract, and the three most relevant of those papers.
The reading. A promoter that loses methylation switches a gene on; a promoter that gains methylation switches it off. Two combinations fit a causal story in cancer: an oncogene switched on by hypomethylation, and a tumour suppressor silenced by hypermethylation. The other two, an oncogene silenced or a tumour suppressor switched on, do not, and are more likely lineage markers that happen to carry a cancer label from another tissue. Most concordant genes have no cancer role in either list; for them the methylation change reports cell identity, not transformation.
In [1]:
import json
import pandas as pd
from IPython.display import Image, display
from pathlib import Path
TAB = Path('../results/tables')
FIG = Path('../results/figures')
pd.set_option('display.width', 160)
pd.set_option('display.max_columns', 30)
pd.set_option('display.max_colwidth', 90)
In [2]:
ann = pd.read_csv(TAB / 'gene_annotation.csv', index_col=0)
summ = json.load(open(TAB / 'gene_annotation_summary.json'))
print('genes annotated:', summ['genes_annotated'], '| with a cancer role:', summ['with_cancer_role'])
pd.Series(summ['cancer_role_counts'], name='genes').to_frame()
genes annotated: 464 | with a cancer role: 46
Out[2]:
| genes | |
|---|---|
| none | 418 |
| oncogene | 20 |
| tumour suppressor | 18 |
| both | 8 |
1. The reading per subgroup¶
In [3]:
display(Image(FIG / 'gene_roles_by_group.png'))
reg = pd.read_csv(TAB / 'gene_regulation_concordant.csv')
pd.crosstab(reg['group'], reg['reading']).reindex(['WNT', 'SHH', 'Group3', 'Group4'])
Out[3]:
| reading | no cancer role annotated | oncogene silenced | oncogene switched on | tumour suppressor silenced | tumour suppressor switched on |
|---|---|---|---|---|---|
| group | |||||
| WNT | 154 | 0 | 4 | 1 | 6 |
| SHH | 126 | 0 | 1 | 1 | 1 |
| Group3 | 61 | 1 | 1 | 0 | 0 |
| Group4 | 76 | 2 | 0 | 0 | 0 |
The genes that fit the causal story, per subgroup, with their names, the evidence source and the number of medulloblastoma papers.
In [4]:
cols = ['group', 'gene', 'gene_name', 'direction', 'oncokb_gene_type', 'cgc_role_in_cancer', 'pubmed_medulloblastoma', 'reading']
fits = reg[reg['reading'].isin(['oncogene switched on', 'tumour suppressor silenced'])]
fits.sort_values(['group', 'pubmed_medulloblastoma'], ascending=[True, False])[cols].reset_index(drop=True)
Out[4]:
| group | gene | gene_name | direction | oncokb_gene_type | cgc_role_in_cancer | pubmed_medulloblastoma | reading | |
|---|---|---|---|---|---|---|---|---|
| 0 | Group3 | IGF1 | insulin like growth factor 1 | promoter hypomethylated, expression up | ONCOGENE | NaN | 15 | oncogene switched on |
| 1 | SHH | SCG5 | secretogranin V | promoter hypomethylated, expression up | ONCOGENE | NaN | 0 | oncogene switched on |
| 2 | SHH | APCDD1 | APC down-regulated 1 | promoter hypermethylated, expression down | TSG | NaN | 0 | tumour suppressor silenced |
| 3 | WNT | SFRP1 | secreted frizzled related protein 1 | promoter hypermethylated, expression down | TSG | NaN | 10 | tumour suppressor silenced |
| 4 | WNT | SYK | spleen associated tyrosine kinase | promoter hypomethylated, expression up | ONCOGENE | NaN | 2 | oncogene switched on |
| 5 | WNT | STAT4 | signal transducer and activator of transcription 4 | promoter hypomethylated, expression up | ONCOGENE | NaN | 1 | oncogene switched on |
| 6 | WNT | DDR2 | discoidin domain receptor tyrosine kinase 2 | promoter hypomethylated, expression up | ONCOGENE | oncogene | 0 | oncogene switched on |
| 7 | WNT | SCG5 | secretogranin V | promoter hypomethylated, expression up | ONCOGENE | NaN | 0 | oncogene switched on |
And the genes that carry a cancer label but change in the other direction. These are the ones to be careful with: a label from leukaemia or breast cancer does not transfer to a cerebellar tumour.
In [5]:
against = reg[reg['reading'].isin(['oncogene silenced', 'tumour suppressor switched on', 'dual role gene changed'])]
against.sort_values(['group', 'pubmed_medulloblastoma'], ascending=[True, False])[cols].reset_index(drop=True)
Out[5]:
| group | gene | gene_name | direction | oncokb_gene_type | cgc_role_in_cancer | pubmed_medulloblastoma | reading | |
|---|---|---|---|---|---|---|---|---|
| 0 | Group3 | SCG5 | secretogranin V | promoter hypermethylated, expression down | ONCOGENE | NaN | 0 | oncogene silenced |
| 1 | Group4 | DDR2 | discoidin domain receptor tyrosine kinase 2 | promoter hypermethylated, expression down | ONCOGENE | oncogene | 0 | oncogene silenced |
| 2 | Group4 | SCG5 | secretogranin V | promoter hypermethylated, expression down | ONCOGENE | NaN | 0 | oncogene silenced |
| 3 | SHH | NDRG1 | N-myc downstream regulated 1 | promoter hypomethylated, expression up | NaN | TSG; fusion | 2 | tumour suppressor switched on |
| 4 | WNT | EPHA3 | EPH receptor A3 | promoter hypomethylated, expression up | TSG | NaN | 4 | tumour suppressor switched on |
| 5 | WNT | SLFN11 | schlafen family member 11 | promoter hypomethylated, expression up | TSG | NaN | 3 | tumour suppressor switched on |
| 6 | WNT | ZNRF3 | zinc and ring finger 3 | promoter hypomethylated, expression up | TSG | NaN | 3 | tumour suppressor switched on |
| 7 | WNT | RNF43 | ring finger protein 43 | promoter hypomethylated, expression up | TSG | TSG | 2 | tumour suppressor switched on |
| 8 | WNT | APCDD1 | APC down-regulated 1 | promoter hypomethylated, expression up | TSG | NaN | 0 | tumour suppressor switched on |
| 9 | WNT | ZFHX3 | zinc finger homeobox 3 | promoter hypomethylated, expression up | TSG | TSG | 0 | tumour suppressor switched on |
2. Signalling map¶
Concordant genes that have a cancer role or sit in a Reactome signal transduction pathway, per subgroup. Position is the expression change, colour the direction of the methylation change, dot size the number of medulloblastoma papers. Genes without any paper are the unexplored part of each list.
In [6]:
display(Image(FIG / 'signalling_map.png'))
3. The most studied genes in each subgroup¶
Literature count is a crude measure of what is known. A concordant gene with many medulloblastoma papers is a known marker and the methylation result confirms it. A concordant gene with none is either new or unimportant; the table of all genes at the end lets the reader decide.
In [7]:
pd.DataFrame({g: [f"{x[0]} ({int(x[1])})" for x in summ['most_cited_in_medulloblastoma_per_group'][g]] for g in ['WNT', 'SHH', 'Group3', 'Group4']})
Out[7]:
| WNT | SHH | Group3 | Group4 | |
|---|---|---|---|---|
| 0 | FAP (29) | GLI2 (70) | GLI2 (70) | OTX2 (61) |
| 1 | SFRP1 (10) | OTX2 (61) | OTX2 (61) | FAP (29) |
| 2 | IMPG2 (4) | FAP (29) | RHO (20) | TF (18) |
| 3 | LOXL1 (4) | SAG (12) | TF (18) | BOC (3) |
| 4 | EPHA3 (4) | SST (5) | IGF1 (15) | COL1A2 (3) |
| 5 | PRAME (3) | IMPG2 (4) | SAG (12) | EYA1 (3) |
| 6 | SLFN11 (3) | BOC (3) | IMPG2 (4) | EOMES (2) |
| 7 | ZNRF3 (3) | COL1A2 (3) | PRAME (3) | RBM24 (2) |
In [8]:
lit = pd.read_csv(TAB / 'gene_literature_top.csv')
topg = reg.sort_values('pubmed_medulloblastoma', ascending=False).drop_duplicates('gene').head(12)['gene']
lit[lit['gene'].isin(topg) & (lit['rank'] == 1)].merge(reg.drop_duplicates('gene')[['gene', 'group', 'direction']], on='gene')[['group', 'gene', 'direction', 'year', 'title']].reset_index(drop=True)
Out[8]:
| group | gene | direction | year | title | |
|---|---|---|---|---|---|
| 0 | WNT | EPHA3 | promoter hypomethylated, expression up | 2025 | Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous sy... |
| 1 | Group4 | FAP | promoter hypermethylated, expression down | 2023 | Turcot Syndrome. |
| 2 | Group3 | GLI2 | promoter hypermethylated, expression down | 2021 | The transcriptional landscape of Shh medulloblastoma. |
| 3 | Group3 | IGF1 | promoter hypomethylated, expression up | 2026 | Targeting tumor-associated macrophage-induced IGF1/PI3K/Zic1 axis triggers SHH medullo... |
| 4 | Group3 | IMPG2 | promoter hypomethylated, expression up | 2026 | Elucidating Tumorigenesis Mechanisms and Assessing Immunotherapeutic Efficacy in Patie... |
| 5 | WNT | LOXL1 | promoter hypomethylated, expression up | 2018 | LncRNA LOXL1-AS1 Promotes the Proliferation and Metastasis of Medulloblastoma by Activ... |
| 6 | Group3 | OTX2 | promoter hypomethylated, expression up | 2022 | Failure of human rhombic lip differentiation underlies medulloblastoma formation. |
| 7 | Group3 | RHO | promoter hypomethylated, expression up | 2019 | Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth. |
| 8 | Group3 | SAG | promoter hypomethylated, expression up | 2010 | Small-molecule modulators of the Sonic Hedgehog signaling pathway. |
| 9 | WNT | SFRP1 | promoter hypermethylated, expression down | 2007 | Loss of suppressor-of-fused function promotes tumorigenesis. |
| 10 | SHH | SST | promoter hypermethylated, expression down | 2018 | Further Investigation About the Expression of SST, GAD2, and PVALB in Medulloblastoma. |
| 11 | Group3 | TF | promoter hypermethylated, expression down | 2017 | Transcription Factor GFI1B in Health and Disease. |
4. The driver genes, annotated¶
The curated driver genes of each subgroup with the same annotation, for comparison. They are the mutated or amplified genes; their methylation does not change (page 5), but their roles and literature anchor the subgroup biology.
In [9]:
drv = pd.read_csv(TAB / 'therapy_driver_genes.csv')[['group', 'gene']]
drv.merge(ann[['gene_name', 'cancer_role', 'oncokb_gene_type', 'cgc_role_in_cancer', 'pubmed_medulloblastoma', 'reactome_top_level']], left_on='gene', right_index=True)
Out[9]:
| group | gene | gene_name | cancer_role | oncokb_gene_type | cgc_role_in_cancer | pubmed_medulloblastoma | reactome_top_level | |
|---|---|---|---|---|---|---|---|---|
| 0 | WNT | CTNNB1 | catenin beta 1 | oncogene | ONCOGENE | fusion; oncogene | 68 | Cell-Cell communication; Cellular responses to stimuli; Chromatin organization; Develo... |
| 1 | WNT | DDX3X | DEAD-box helicase 3 X-linked | tumour suppressor | TSG | TSG | 21 | Disease; Immune System |
| 2 | WNT | SMARCA4 | SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 | tumour suppressor | TSG | TSG; fusion | 26 | Cell-Cell communication; Chromatin organization; Developmental Biology; Gene expressio... |
| 3 | WNT | TP53 | tumor protein p53 | both | TSG | TSG; fusion; oncogene | 221 | Cell Cycle; Cellular responses to stimuli; DNA Repair; Developmental Biology; Disease;... |
| 4 | WNT | KMT2D | lysine methyltransferase 2D | both | TSG | Oncogene, TSG | 12 | Chromatin organization; Developmental Biology; Disease; Gene expression (Transcription... |
| 5 | SHH | PTCH1 | patched 1 | tumour suppressor | TSG | TSG; fusion | 233 | Signal Transduction |
| 6 | SHH | SUFU | SUFU negative regulator of hedgehog signaling | tumour suppressor | TSG | TSG | 106 | Signal Transduction |
| 7 | SHH | SMO | smoothened, frizzled class receptor | oncogene | ONCOGENE | oncogene | 211 | Organelle biogenesis and maintenance; Signal Transduction |
| 8 | SHH | GLI2 | GLI family zinc finger 2 | none | NaN | NaN | 70 | Gene expression (Transcription); Signal Transduction |
| 9 | SHH | MYCN | MYCN proto-oncogene, bHLH transcription factor | oncogene | ONCOGENE | fusion; oncogene | 176 | Cell-Cell communication; Immune System; Signal Transduction |
| 10 | SHH | TP53 | tumor protein p53 | both | TSG | TSG; fusion; oncogene | 221 | Cell Cycle; Cellular responses to stimuli; DNA Repair; Developmental Biology; Disease;... |
| 11 | SHH | TERT | telomerase reverse transcriptase | both | ONCOGENE | TSG, oncogene | 18 | Cell Cycle; Developmental Biology; Signal Transduction |
| 12 | SHH | KMT2D | lysine methyltransferase 2D | both | TSG | Oncogene, TSG | 12 | Chromatin organization; Developmental Biology; Disease; Gene expression (Transcription... |
| 13 | SHH | DDX3X | DEAD-box helicase 3 X-linked | tumour suppressor | TSG | TSG | 21 | Disease; Immune System |
| 14 | Group3 | MYC | MYC proto-oncogene, bHLH transcription factor | oncogene | ONCOGENE | oncogene, fusion | 500 | Cell Cycle; Cell-Cell communication; Cellular responses to stimuli; Developmental Biol... |
| 15 | Group3 | GFI1 | growth factor independent 1 transcriptional repressor | none | NaN | NaN | 11 | Developmental Biology |
| 16 | Group3 | GFI1B | growth factor independent 1B transcriptional repressor | none | NaN | NaN | 7 | NaN |
| 17 | Group3 | OTX2 | orthodenticle homeobox 2 | none | NaN | NaN | 61 | Developmental Biology |
| 18 | Group3 | SMARCA4 | SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 | tumour suppressor | TSG | TSG; fusion | 26 | Cell-Cell communication; Chromatin organization; Developmental Biology; Gene expressio... |
| 19 | Group3 | KBTBD4 | kelch repeat and BTB domain containing 4 | none | INSUFFICIENT_EVIDENCE | NaN | 10 | NaN |
| 20 | Group4 | KDM6A | lysine demethylase 6A | both | TSG | TSG; oncogene | 11 | Chromatin organization; Developmental Biology; Gene expression (Transcription); Immune... |
| 21 | Group4 | PRDM6 | PR/SET domain 6 | none | NaN | NaN | 9 | NaN |
| 22 | Group4 | SNCAIP | synuclein alpha interacting protein | none | NaN | NaN | 7 | Metabolism of proteins |
| 23 | Group4 | ZMYM3 | zinc finger MYM-type containing 3 | tumour suppressor | TSG | NaN | 3 | NaN |
| 24 | Group4 | KBTBD4 | kelch repeat and BTB domain containing 4 | none | INSUFFICIENT_EVIDENCE | NaN | 10 | NaN |
| 25 | Group4 | MYCN | MYCN proto-oncogene, bHLH transcription factor | oncogene | ONCOGENE | fusion; oncogene | 176 | Cell-Cell communication; Immune System; Signal Transduction |
| 26 | Group4 | OTX2 | orthodenticle homeobox 2 | none | NaN | NaN | 61 | Developmental Biology |
| 27 | Group4 | CDK6 | cyclin dependent kinase 6 | oncogene | ONCOGENE | fusion; oncogene | 30 | Cell Cycle; Cellular responses to stimuli; Disease; Gene expression (Transcription) |
5. Reading the biology, subgroup by subgroup¶
First, the overall count. Of 464 annotated genes, 46 carry a curated cancer role. Of the 325 concordant genes, 262 have never been mentioned together with medulloblastoma on PubMed. Both numbers say the same thing as page 7: the genes whose methylation defines a subgroup are mostly lineage genes, not cancer genes. That is expected for a tumour classified by cell of origin, and it is the reason the classifier works on FFPE blocks from another laboratory.
WNT. This is the subgroup where the reading has the most content, and the most instructive case is the one that looks wrong. Six tumour suppressors are switched on: RNF43, ZNRF3, APCDD1, ZFHX3, EPHA3 and SLFN11. RNF43 and ZNRF3 are E3 ubiquitin ligases that remove Frizzled receptors from the cell surface; APCDD1 is a membrane Wnt inhibitor. All three are transcriptional targets of beta-catenin, as are AXIN2, NKD1, NOTUM and DKK1 from page 7. They form the negative feedback loop of the pathway: when Wnt signalling fires, the cell induces its own brakes. In WNT medulloblastoma, CTNNB1 carries a mutation in the degradation motif, so beta-catenin is stable no matter what happens at the receptor. The brakes are induced and have nothing to act on. The methylation layer splits them in two: RNF43, ZNRF3, APCDD1 and SP5 are hypomethylated as well as expressed, while AXIN2, NKD1, NOTUM and DKK1 are expressed with no promoter change. "Tumour suppressor switched on" is here the signature of a pathway stuck on downstream of the point where the suppressor acts. The one tumour suppressor silenced, SFRP1, a secreted Wnt antagonist, is the classic promoter hypermethylation event of Wnt-driven cancers, and has ten medulloblastoma papers. The oncogenes switched on, SYK and STAT4, are immune signalling kinases and transcription factors with no medulloblastoma literature; they may reflect the immune and stromal content of WNT tumours rather than the tumour cell, and are leads at most.
SHH. Almost nothing with a cancer label is concordant. GLI2 and BOC are the pathway-level hits and carry the most literature (70 and 3 papers). APCDD1 silenced and NDRG1 switched on are the only labelled genes; NDRG1 is a hypoxia and differentiation gene. The SHH concordant list is dominated by genes of the desmoplastic stroma and of neuronal differentiation. The Hedgehog pathway itself is activated by mutation, as page 7 shows, and the methylation layer adds the context of the lineage, not the driver.
Group 3. IGF1 is the one oncogene switched on, with 15 medulloblastoma papers; insulin-like growth factor signalling is an established growth signal in Group 3 models and a candidate target. The rest of the labelled list is the photoreceptor program (RHO, GNAT1, GNGT1, GNGT2 in the signalling map), which is lineage identity, and GLI2 and OTX2 silenced or switched on as the mirror image of SHH and Group 4.
Group 4. No cancer-role gene fits the causal story. DDR2 and SCG5 are silenced, which reads as lineage again. The most cited concordant genes, OTX2, EYA1, EOMES and RBM24, are developmental transcription factors and RNA-binding proteins of the cerebellar lineage. Group 4 stays what the literature says it is: the subgroup defined by its cell of origin rather than by a driver pathway, with KDM6A, PRDM6 and SNCAIP as mutated or rearranged genes whose promoters do not change.
Caveats on the counts. PubMed counts use the gene symbol in title or abstract, so symbols that are also common abbreviations are inflated: FAP (familial adenomatous polyposis, itself linked to medulloblastoma), SAG (sagittal), SST, TF and RHO. Those counts should be read as upper bounds. Twenty-nine symbols come from the 2011 Illumina manifest and are no longer current (C1orf61, HIST1H3E, SEPP1 and others); they have no name in the table. Oncogene and tumour suppressor labels come from pan-cancer curation and do not transfer automatically to a cerebellar tumour of childhood; the WNT feedback genes are the proof.
5b. Cancer genes in the expression-only layer¶
Page 5 showed that most differential expression happens without a promoter change. The cancer genes in that layer are the ones a methylation-only view would miss. They are listed per subgroup with their OncoKB type; the curated drivers among them are flagged. This is where MYC, MYCN, GLI1, PTCH1 and the beta-catenin targets AXIN2, LEF1 and LGR5 sit.
In [10]:
eo = pd.read_csv(TAB / 'expression_only_genes.csv')
eo = eo[eo['oncokb_gene_type'].notna() & (eo['oncokb_gene_type'] != '')]
eo.sort_values(['group', 'expr_delta'], ascending=[True, False])[['group', 'gene', 'direction', 'expr_delta', 'oncokb_gene_type', 'curated_driver', 'nanostring_2012']].reset_index(drop=True)
Out[10]:
| group | gene | direction | expr_delta | oncokb_gene_type | curated_driver | nanostring_2012 | |
|---|---|---|---|---|---|---|---|
| 0 | Group3 | MYC | expression up | 2.1190 | ONCOGENE | True | False |
| 1 | Group3 | BCL11B | expression up | 1.1993 | TSG | False | False |
| 2 | Group3 | PTPN13 | expression up | 1.1823 | TSG | False | False |
| 3 | Group3 | JAZF1 | expression up | 1.1446 | ONCOGENE | False | False |
| 4 | Group3 | SGK1 | expression up | 1.1337 | ONCOGENE | False | False |
| ... | ... | ... | ... | ... | ... | ... | ... |
| 206 | WNT | TLE2 | expression down | -2.3420 | INSUFFICIENT_EVIDENCE | False | False |
| 207 | WNT | ASXL3 | expression down | -2.5500 | ONCOGENE | False | False |
| 208 | WNT | TOX | expression down | -2.6262 | INSUFFICIENT_EVIDENCE | False | False |
| 209 | WNT | ERBB4 | expression down | -2.6373 | ONCOGENE | False | False |
| 210 | WNT | RELN | expression down | -3.1200 | INSUFFICIENT_EVIDENCE | False | False |
211 rows × 7 columns
6. Every annotated gene¶
The full table, one row per gene: name, which analyses it appears in, cancer role and sources,
hallmarks, Reactome pathways, PubMed counts, the Open Targets medulloblastoma association score and
the NCBI summary. Also in results/tables/gene_annotation.csv.
In [11]:
pd.set_option('display.max_rows', 500)
ann.sort_values('pubmed_medulloblastoma', ascending=False)[['gene_name', 'in_sets', 'cancer_role', 'oncokb_gene_type', 'cgc_role_in_cancer', 'pubmed_medulloblastoma', 'pubmed_cancer', 'reactome_top_level']]
Out[11]:
| gene_name | in_sets | cancer_role | oncokb_gene_type | cgc_role_in_cancer | pubmed_medulloblastoma | pubmed_cancer | reactome_top_level | |
|---|---|---|---|---|---|---|---|---|
| gene | ||||||||
| SHH | sonic hedgehog signaling molecule | pathway_flow | none | NaN | NaN | 1118 | 2415 | Developmental Biology; Disease; Signal Transduction |
| MYC | MYC proto-oncogene, bHLH transcription factor | driver; pathway_flow | oncogene | ONCOGENE | oncogene, fusion | 500 | 27277 | Cell Cycle; Cell-Cell communication; Cellular responses to stimuli; Developmental Biol... |
| PTCH1 | patched 1 | driver; pathway_flow | tumour suppressor | TSG | TSG; fusion | 233 | 910 | Signal Transduction |
| TP53 | tumor protein p53 | driver | both | TSG | TSG; fusion; oncogene | 221 | 23596 | Cell Cycle; Cellular responses to stimuli; DNA Repair; Developmental Biology; Disease;... |
| SMO | smoothened, frizzled class receptor | driver; pathway_flow | oncogene | ONCOGENE | oncogene | 211 | 1289 | Organelle biogenesis and maintenance; Signal Transduction |
| GLI1 | GLI family zinc finger 1 | pathway_flow | oncogene | ONCOGENE | NaN | 186 | 1885 | Signal Transduction |
| MYCN | MYCN proto-oncogene, bHLH transcription factor | driver; pathway_flow | oncogene | ONCOGENE | fusion; oncogene | 176 | 2907 | Cell-Cell communication; Immune System; Signal Transduction |
| SUFU | SUFU negative regulator of hedgehog signaling | driver; pathway_flow | tumour suppressor | TSG | TSG | 106 | 301 | Signal Transduction |
| APC | APC regulator of Wnt signaling pathway | pathway_flow | tumour suppressor | TSG | TSG | 78 | 13688 | Disease; Metabolism of proteins; Programmed Cell Death; Signal Transduction |
| GLI2 | GLI family zinc finger 2 | concordant; driver; pathway_flow | none | NaN | NaN | 70 | 614 | Gene expression (Transcription); Signal Transduction |
| CTNNB1 | catenin beta 1 | driver; pathway_flow | oncogene | ONCOGENE | fusion; oncogene | 68 | 2994 | Cell-Cell communication; Cellular responses to stimuli; Chromatin organization; Develo... |
| OTX2 | orthodenticle homeobox 2 | concordant; driver; pathway_flow | none | NaN | NaN | 61 | 96 | Developmental Biology |
| CDK6 | cyclin dependent kinase 6 | driver | oncogene | ONCOGENE | fusion; oncogene | 30 | 2474 | Cell Cycle; Cellular responses to stimuli; Disease; Gene expression (Transcription) |
| FAP | fibroblast activation protein alpha | concordant | none | NaN | NaN | 29 | 4189 | NaN |
| GLI3 | GLI family zinc finger 3 | pathway_flow | none | NaN | NaN | 27 | 214 | Gene expression (Transcription); Signal Transduction |
| SMARCA4 | SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 | driver | tumour suppressor | TSG | TSG; fusion | 26 | 1292 | Cell-Cell communication; Chromatin organization; Developmental Biology; Gene expressio... |
| CCND1 | cyclin D1 | pathway_flow | oncogene | ONCOGENE | fusion; oncogene | 23 | 3278 | Cell Cycle; Chromatin organization; Developmental Biology; Disease; Gene expression (T... |
| DDX3X | DEAD-box helicase 3 X-linked | driver | tumour suppressor | TSG | TSG | 21 | 192 | Disease; Immune System |
| RHO | rhodopsin | concordant; pathway_flow | none | NaN | NaN | 20 | 9472 | Organelle biogenesis and maintenance; Sensory Perception; Signal Transduction |
| CXCR4 | C-X-C motif chemokine receptor 4 | top_attributed_cpg | oncogene | ONCOGENE | oncogene | 20 | 5693 | Developmental Biology; Disease; Reproduction; Signal Transduction |
| TERT | telomerase reverse transcriptase | driver | both | ONCOGENE | TSG, oncogene | 18 | 5452 | Cell Cycle; Developmental Biology; Signal Transduction |
| TF | transferrin | concordant | none | NaN | NaN | 18 | 5316 | Hemostasis; Metabolism of proteins; Transport of small molecules; Vesicle-mediated tra... |
| IGF1 | insulin like growth factor 1 | concordant | oncogene | ONCOGENE | NaN | 15 | 5398 | Hemostasis; Metabolism of proteins; Signal Transduction |
| PTCH2 | patched 2 | pathway_flow | none | NaN | NaN | 13 | 76 | Signal Transduction |
| SAG | S-antigen visual arrestin | concordant; pathway_flow; network_hub | none | NaN | NaN | 12 | 380 | Sensory Perception |
| KMT2D | lysine methyltransferase 2D | driver | both | TSG | Oncogene, TSG | 12 | 701 | Chromatin organization; Developmental Biology; Disease; Gene expression (Transcription... |
| GFI1 | growth factor independent 1 transcriptional repressor | driver | none | NaN | NaN | 11 | 133 | Developmental Biology |
| LEF1 | lymphoid enhancer binding factor 1 | pathway_flow | both | ONCOGENE | TSG; oncogene | 11 | 787 | Developmental Biology; Gene expression (Transcription); Immune System; Signal Transduc... |
| KDM6A | lysine demethylase 6A | driver | both | TSG | TSG; oncogene | 11 | 393 | Chromatin organization; Developmental Biology; Gene expression (Transcription); Immune... |
| KBTBD4 | kelch repeat and BTB domain containing 4 | driver | none | INSUFFICIENT_EVIDENCE | NaN | 10 | 21 | NaN |
| DKK1 | dickkopf Wnt signaling pathway inhibitor 1 | pathway_flow | none | INSUFFICIENT_EVIDENCE | NaN | 10 | 1091 | Developmental Biology; Disease; Signal Transduction |
| CCND2 | cyclin D2 | pathway_flow | oncogene | ONCOGENE | fusion; oncogene | 10 | 483 | Cell Cycle; Disease; Gene expression (Transcription) |
| SFRP1 | secreted frizzled related protein 1 | concordant; pathway_flow | tumour suppressor | TSG | NaN | 10 | 646 | Signal Transduction |
| PRDM6 | PR/SET domain 6 | driver | none | NaN | NaN | 9 | 17 | NaN |
| HHIP | hedgehog interacting protein | pathway_flow | none | NaN | NaN | 8 | 112 | Signal Transduction |
| SNCAIP | synuclein alpha interacting protein | driver | none | NaN | NaN | 7 | 14 | Metabolism of proteins |
| GFI1B | growth factor independent 1B transcriptional repressor | driver | none | NaN | NaN | 7 | 32 | NaN |
| AXIN1 | axin 1 | pathway_flow | tumour suppressor | TSG | TSG | 6 | 361 | Disease; Gene expression (Transcription); Metabolism of proteins; Signal Transduction |
| CRX | cone-rod homeobox | pathway_flow | none | NaN | NaN | 6 | 49 | NaN |
| SST | somatostatin | concordant | none | NaN | NaN | 5 | 893 | Gene expression (Transcription); Signal Transduction |
| IMPG2 | interphotoreceptor matrix proteoglycan 2 | concordant; pathway_flow | none | NaN | NaN | 4 | 4 | NaN |
| LOXL1 | lysyl oxidase like 1 | concordant | none | NaN | NaN | 4 | 151 | Extracellular matrix organization |
| AXIN2 | axin 2 | pathway_flow | tumour suppressor | TSG | TSG | 4 | 680 | Chromatin organization; Metabolism of proteins; Signal Transduction |
| AFP | alpha fetoprotein | top_attributed_cpg | none | NaN | NaN | 4 | 10898 | Metabolism of proteins |
| EPHA3 | EPH receptor A3 | concordant | tumour suppressor | TSG | NaN | 4 | 180 | Developmental Biology |
| WIF1 | Wnt inhibitory factor 1 | pathway_flow | tumour suppressor | TSG | TSG; fusion | 3 | 377 | Signal Transduction |
| ZMYM3 | zinc finger MYM-type containing 3 | driver | tumour suppressor | TSG | NaN | 3 | 16 | NaN |
| ZNRF3 | zinc and ring finger 3 | concordant | tumour suppressor | TSG | NaN | 3 | 126 | Signal Transduction |
| WNT1 | Wnt family member 1 | pathway_flow | none | NaN | NaN | 3 | 866 | Developmental Biology; Signal Transduction |
| WNT3 | Wnt family member 3 | pathway_flow | none | NaN | NaN | 3 | 189 | Signal Transduction |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | concordant | none | NaN | NaN | 3 | 53 | DNA Repair; Developmental Biology |
| BOC | BOC cell adhesion associated, oncogene regulated | concordant; pathway_flow; network_hub | none | NaN | NaN | 3 | 413 | Developmental Biology; Signal Transduction |
| COL1A2 | collagen type I alpha 2 chain | concordant | none | NaN | NaN | 3 | 424 | Developmental Biology; Disease; Extracellular matrix organization; Hemostasis; Immune ... |
| LGR5 | leucine rich repeat containing G protein-coupled receptor 5 | pathway_flow | oncogene | ONCOGENE | NaN | 3 | 1188 | Signal Transduction |
| PRAME | PRAME nuclear receptor transcriptional regulator | concordant | none | NaN | NaN | 3 | 557 | NaN |
| SLFN11 | schlafen family member 11 | concordant | tumour suppressor | TSG | NaN | 3 | 204 | NaN |
| NDRG1 | N-myc downstream regulated 1 | concordant | tumour suppressor | NaN | TSG; fusion | 2 | 581 | Gene expression (Transcription) |
| ABCA1 | ATP binding cassette subfamily A member 1 | concordant | none | NaN | NaN | 2 | 488 | Disease; Metabolism; Signal Transduction; Transport of small molecules |
| DKK4 | dickkopf Wnt signaling pathway inhibitor 4 | concordant | none | INSUFFICIENT_EVIDENCE | NaN | 2 | 84 | Disease; Signal Transduction |
| EOMES | eomesodermin | concordant | none | NaN | NaN | 2 | 273 | Developmental Biology; Reproduction |
| DKK2 | dickkopf Wnt signaling pathway inhibitor 2 | pathway_flow | none | INSUFFICIENT_EVIDENCE | NaN | 2 | 115 | Chromatin organization; Disease; Signal Transduction |
| GAS1 | growth arrest specific 1 | pathway_flow | none | NaN | NaN | 2 | 113 | Signal Transduction |
| MMP14 | matrix metallopeptidase 14 | concordant | none | NaN | NaN | 2 | 901 | Cellular responses to stimuli; Extracellular matrix organization; Signal Transduction |
| PCDH9 | protocadherin 9 | top_attributed_cpg | none | NaN | NaN | 2 | 41 | NaN |
| RNF43 | ring finger protein 43 | concordant | tumour suppressor | TSG | TSG | 2 | 406 | Disease; Signal Transduction |
| TBR1 | T-box brain transcription factor 1 | concordant | none | NaN | NaN | 2 | 17 | NaN |
| SYK | spleen associated tyrosine kinase | concordant | oncogene | ONCOGENE | NaN | 2 | 974 | Disease; Hemostasis; Immune System; Signal Transduction |
| RBM24 | RNA binding motif protein 24 | concordant; network_hub; top_attributed_cpg | none | NaN | NaN | 2 | 34 | NaN |
| PPP2R2C | protein phosphatase 2 regulatory subunit Bgamma | concordant | none | NaN | NaN | 2 | 21 | NaN |
| NEUROG1 | neurogenin 1 | concordant | none | NaN | NaN | 2 | 101 | NaN |
| PTGDS | prostaglandin D2 synthase | concordant | none | NaN | NaN | 2 | 80 | Developmental Biology; Metabolism |
| LRP1B | LDL receptor related protein 1B | top_attributed_cpg | tumour suppressor | TSG | TSG | 2 | 362 | NaN |
| CUX1 | cut like homeobox 1 | top_attributed_cpg | both | TSG | TSG, oncogene | 2 | 115 | Disease; Vesicle-mediated transport |
| NKD1 | NKD inhibitor of Wnt signaling pathway 1 | pathway_flow | none | NaN | NaN | 1 | 77 | NaN |
| SLITRK6 | SLIT and NTRK like family member 6 | concordant | none | NaN | NaN | 1 | 13 | Neuronal System |
| ACTC1 | actin alpha cardiac muscle 1 | concordant | none | NaN | NaN | 1 | 37 | Cell-Cell communication; Extracellular matrix organization; Muscle contraction; Signal... |
| ATP1A2 | ATPase Na+/K+ transporting subunit alpha 2 | concordant | none | NaN | NaN | 1 | 30 | Disease; Muscle contraction; Transport of small molecules |
| STAT4 | signal transducer and activator of transcription 4 | concordant | oncogene | ONCOGENE | NaN | 1 | 331 | Developmental Biology; Immune System |
| RREB1 | ras responsive element binding protein 1 | concordant | none | NaN | NaN | 1 | 109 | NaN |
| SLC8A1 | solute carrier family 8 member A1 | top_attributed_cpg | none | NaN | NaN | 1 | 45 | Hemostasis; Muscle contraction; Transport of small molecules |
| NFASC | neurofascin | top_attributed_cpg | none | NaN | NaN | 1 | 14 | Developmental Biology; Immune System |
| NET1 | neuroepithelial cell transforming 1 | concordant | none | NaN | NaN | 1 | 103 | Signal Transduction |
| PAM | peptidylglycine alpha-amidating monooxygenase | concordant | none | NaN | NaN | 1 | 1305 | NaN |
| OPCML | opioid binding protein/cell adhesion molecule like | top_attributed_cpg | none | NaN | NaN | 1 | 79 | Metabolism of proteins |
| NRL | neural retina leucine zipper | concordant; pathway_flow | none | NaN | NaN | 1 | 86 | NaN |
| PDC | phosducin | concordant | none | NaN | NaN | 1 | 1255 | NaN |
| PRLR | prolactin receptor | concordant | none | NaN | NaN | 1 | 324 | Immune System |
| RCVRN | recoverin | concordant; pathway_flow | none | NaN | NaN | 1 | 4 | Sensory Perception |
| CD200 | CD200 molecule | top_attributed_cpg | none | NaN | NaN | 1 | 315 | Immune System |
| RORB | RAR related orphan receptor B | pathway_flow | none | NaN | NaN | 1 | 39 | Circadian clock; Gene expression (Transcription) |
| CIDEB | cell death inducing DFFA like effector b | concordant | none | NaN | NaN | 1 | 20 | NaN |
| CLIC1 | CLIC family member 1 | concordant | none | NaN | NaN | 1 | 152 | NaN |
| CMKLR1 | chemerin chemokine-like receptor 1 | concordant | none | NaN | NaN | 1 | 86 | Signal Transduction |
| MTSS1 | MTSS I-BAR domain containing 1 | concordant | none | NaN | NaN | 1 | 142 | NaN |
| MYT1L | myelin transcription factor 1 like | top_attributed_cpg | none | NaN | NaN | 1 | 23 | NaN |
| KHDRBS2 | KH RNA binding domain containing, signal transduction associated 2 | concordant | none | NaN | NaN | 1 | 13 | Signal Transduction |
| KL | klotho | concordant | none | NaN | NaN | 1 | 608 | Disease; Signal Transduction |
| DAPK1 | death associated protein kinase 1 | concordant | none | NaN | NaN | 1 | 430 | Programmed Cell Death |
| LUM | lumican | concordant | none | NaN | NaN | 1 | 195 | Disease; Extracellular matrix organization; Metabolism |
| LRP5 | LDL receptor related protein 5 | pathway_flow | both | ONCOGENE_AND_TSG | NaN | 1 | 256 | Disease; Signal Transduction |
| CDCA7L | cell division cycle associated 7 like | top_attributed_cpg | none | NaN | NaN | 1 | 15 | NaN |
| MAPK8IP3 | mitogen-activated protein kinase 8 interacting protein 3 | top_attributed_cpg | none | NaN | NaN | 1 | 7 | NaN |
| LMX1A | LIM homeobox transcription factor 1 alpha | concordant; top_attributed_cpg | none | NaN | NaN | 1 | 43 | NaN |
| COLEC12 | collectin subfamily member 12 | concordant | none | NaN | NaN | 1 | 25 | Immune System; Vesicle-mediated transport |
| KIF7 | kinesin family member 7 | pathway_flow | none | NaN | NaN | 1 | 24 | Signal Transduction |
| LGALS1 | galectin 1 | concordant | none | NaN | NaN | 1 | 172 | Metabolism of proteins |
| HEPACAM | hepatic and glial cell adhesion molecule | top_attributed_cpg | none | NaN | NaN | 1 | 45 | NaN |
| DDX31 | DEAD-box helicase 31 | concordant | none | NaN | NaN | 1 | 7 | NaN |
| DCC | DCC netrin 1 receptor | concordant | none | NaN | NaN | 1 | 1558 | Developmental Biology; Programmed Cell Death |
| FMOD | fibromodulin | concordant | none | NaN | NaN | 1 | 55 | Disease; Extracellular matrix organization; Metabolism |
| HDAC9 | histone deacetylase 9 | concordant | none | NaN | NaN | 1 | 147 | Developmental Biology; Disease; Gene expression (Transcription); Signal Transduction |
| GPX8 | glutathione peroxidase 8 (putative) | concordant | none | NaN | NaN | 1 | 54 | Cellular responses to stimuli |
| GSK3B | glycogen synthase kinase 3 beta | pathway_flow | oncogene | ONCOGENE | NaN | 1 | 301 | Cell Cycle; Cellular responses to stimuli; Developmental Biology; Disease; Gene expres... |
| EBF3 | EBF transcription factor 3 | top_attributed_cpg | none | NaN | NaN | 1 | 33 | NaN |
| FEZ1 | fasciculation and elongation protein zeta 1 | top_attributed_cpg | none | NaN | NaN | 1 | 39 | NaN |
| FOXP2 | forkhead box P2 | concordant | none | NaN | NaN | 1 | 95 | Cell-Cell communication |
| VTN | vitronectin | concordant | none | NaN | NaN | 1 | 65 | Developmental Biology; Disease; Extracellular matrix organization; Immune System |
| EYS | EGF-like photoreceptor maintenance factor | concordant | none | NaN | NaN | 1 | 13 | NaN |
| TULP1 | TUB like protein 1 | concordant | none | NaN | NaN | 1 | 6 | NaN |
| USH2A | usherin | concordant | none | NaN | NaN | 1 | 37 | NaN |
| ZIC4 | Zic family zinc finger 4 | concordant; top_attributed_cpg | none | NaN | NaN | 1 | 51 | NaN |
| WNK4 | WNK lysine deficient protein kinase 4 | top_attributed_cpg | none | NaN | NaN | 1 | 18 | Transport of small molecules |
| AMHR2 | anti-Mullerian hormone receptor type 2 | concordant | none | NaN | NaN | 0 | 64 | Signal Transduction |
| VWDE | von Willebrand factor D and EGF domains | concordant | none | NaN | NaN | 0 | 3 | NaN |
| WNK2 | WNK lysine deficient protein kinase 2 | concordant | none | NaN | NaN | 0 | 39 | Transport of small molecules |
| WNT16 | Wnt family member 16 | concordant | none | NaN | NaN | 0 | 47 | Signal Transduction |
| ZFHX3 | zinc finger homeobox 3 | concordant | tumour suppressor | TSG | TSG | 0 | 83 | Gene expression (Transcription) |
| ZNF154 | zinc finger protein 154 | concordant | none | NaN | NaN | 0 | 34 | Gene expression (Transcription) |
| ARSB | arylsulfatase B | top_attributed_cpg | none | NaN | NaN | 0 | 22 | Disease; Immune System; Metabolism; Metabolism of proteins |
| ARL6IP6 | ARF like GTPase 6 interacting protein 6 | top_attributed_cpg | none | NaN | NaN | 0 | 0 | NaN |
| ARL4C | ARF like GTPase 4C | concordant | none | NaN | NaN | 0 | 57 | Signal Transduction |
| ARHGAP28 | Rho GTPase activating protein 28 | concordant | none | NaN | NaN | 0 | 11 | Signal Transduction |
| APCDD1 | APC down-regulated 1 | concordant; network_hub | tumour suppressor | TSG | NaN | 0 | 25 | NaN |
| APBA2 | amyloid beta precursor protein binding family A member 2 | concordant; network_hub | none | NaN | NaN | 0 | 8 | Neuronal System |
| ANXA2P2 | annexin A2 pseudogene 2 | concordant | none | NaN | NaN | 0 | 12 | NaN |
| ANKRD30B | ankyrin repeat domain 30B | concordant | none | NaN | NaN | 0 | 2 | NaN |
| ANGPTL2 | angiopoietin like 2 | concordant | none | NaN | NaN | 0 | 112 | NaN |
| TMPRSS11E | transmembrane serine protease 11E | top_attributed_cpg | none | NaN | NaN | 0 | 9 | NaN |
| TMEM51 | transmembrane protein 51 | concordant | none | NaN | NaN | 0 | 10 | NaN |
| TMEM201 | transmembrane protein 201 | top_attributed_cpg | none | NaN | NaN | 0 | 6 | NaN |
| TMEM132C | transmembrane protein 132C | concordant; network_hub | none | NaN | NaN | 0 | 6 | NaN |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | concordant | none | NaN | NaN | 0 | 15 | Immune System |
| TM4SF19 | transmembrane 4 L six family member 19 | top_attributed_cpg | none | NaN | NaN | 0 | 10 | NaN |
| THSD4 | thrombospondin type 1 domain containing 4 | top_attributed_cpg | none | NaN | NaN | 0 | 15 | Disease; Metabolism of proteins |
| DSCAML1 | DS cell adhesion molecule like 1 | concordant | none | NaN | NaN | 0 | 4 | Developmental Biology |
| DSC2 | desmocollin 2 | concordant | none | NaN | NaN | 0 | 76 | Developmental Biology |
| DPY19L2P2 | DPY19L2 pseudogene 2 | concordant | none | NaN | NaN | 0 | 0 | NaN |
| DNAH2 | dynein axonemal heavy chain 2 | concordant | none | NaN | NaN | 0 | 5 | NaN |
| DMRTA1 | DMRT like family A1 | concordant | none | NaN | NaN | 0 | 7 | NaN |
| DMGDH | dimethylglycine dehydrogenase | concordant | none | NaN | NaN | 0 | 6 | Metabolism |
| DLG2 | discs large MAGUK scaffold protein 2 | top_attributed_cpg | none | NaN | NaN | 0 | 44 | Neuronal System; Signal Transduction |
| FLJ22536 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 3 | NaN |
| FGF20 | fibroblast growth factor 20 | concordant | none | NaN | NaN | 0 | 40 | Disease; Signal Transduction |
| FEZF2 | FEZ family zinc finger 2 | concordant | none | NaN | NaN | 0 | 7 | NaN |
| FAM198B | NaN | concordant | none | NaN | NaN | 0 | 12 | NaN |
| FAM174B | family with sequence similarity 174 member B | concordant | none | NaN | NaN | 0 | 6 | NaN |
| FABP7 | fatty acid binding protein 7 | concordant | none | NaN | NaN | 0 | 111 | Metabolism; Signal Transduction |
| ESM1 | endothelial cell specific molecule 1 | concordant | none | NaN | NaN | 0 | 170 | NaN |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | concordant | none | NaN | NaN | 0 | 109 | Metabolism |
| EMP3 | epithelial membrane protein 3 (MAM blood group) | concordant | none | NaN | NaN | 0 | 79 | NaN |
| GLYATL2 | glycine-N-acyltransferase like 2 | concordant; network_hub | none | NaN | NaN | 0 | 5 | Drug ADME; Metabolism |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | concordant | none | NaN | NaN | 0 | 9 | NaN |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase like 6 | top_attributed_cpg | none | NaN | NaN | 0 | 10 | Metabolism of proteins |
| GALM | galactose mutarotase | concordant | none | NaN | NaN | 0 | 15 | Disease; Metabolism |
| GAK | cyclin G associated kinase | top_attributed_cpg | none | NaN | NaN | 0 | 34 | Vesicle-mediated transport |
| FZD7 | frizzled class receptor 7 | concordant; pathway_flow | none | NaN | NaN | 0 | 228 | Disease; Signal Transduction |
| FZD6 | frizzled class receptor 6 | concordant | none | NaN | NaN | 0 | 95 | Disease; Signal Transduction |
| FRMPD2 | FERM and PDZ domain containing 2 | concordant | none | NaN | NaN | 0 | 1 | NaN |
| FRMD4A | FERM domain containing 4A | top_attributed_cpg | none | NaN | NaN | 0 | 11 | NaN |
| FOXN2 | forkhead box N2 | top_attributed_cpg | none | NaN | NaN | 0 | 22 | NaN |
| FLJ42709 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 0 | NaN |
| ELAVL4 | ELAV like RNA binding protein 4 | concordant | none | NaN | NaN | 0 | 24 | NaN |
| EHHADH | enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase | concordant | none | NaN | NaN | 0 | 50 | Metabolism; Protein localization |
| EFNA5 | ephrin A5 | top_attributed_cpg | none | NaN | NaN | 0 | 38 | Developmental Biology |
| DSG2 | desmoglein 2 | concordant | none | NaN | NaN | 0 | 158 | Developmental Biology; Programmed Cell Death; Signal Transduction |
| DSCR8 | Down syndrome critical region 8 | concordant | none | NaN | NaN | 0 | 9 | NaN |
| HIST1H4F | NaN | concordant | none | NaN | NaN | 0 | 12 | NaN |
| HIST1H4D | NaN | concordant | none | NaN | NaN | 0 | 2 | NaN |
| HIST1H3J | NaN | concordant | none | NaN | NaN | 0 | 8 | NaN |
| HIST1H3E | NaN | concordant | none | NaN | NaN | 0 | 1 | NaN |
| H2AFJ | NaN | concordant | none | NaN | NaN | 0 | 13 | NaN |
| GUCY1B3 | NaN | concordant | none | NaN | NaN | 0 | 5 | NaN |
| GUCA1A | guanylate cyclase activator 1A | pathway_flow | none | NaN | NaN | 0 | 2 | Sensory Perception |
| GSG1 | germ cell associated 1 | concordant | none | NaN | NaN | 0 | 1 | NaN |
| GRK1 | G protein-coupled receptor kinase 1 | concordant | none | NaN | NaN | 0 | 10 | Sensory Perception |
| GPX7 | glutathione peroxidase 7 | concordant; network_hub | none | NaN | NaN | 0 | 45 | Cellular responses to stimuli |
| GPR153 | G protein-coupled receptor 153 | top_attributed_cpg | none | NaN | NaN | 0 | 2 | NaN |
| GNGT2 | G protein subunit gamma transducin 2 | concordant | none | NaN | NaN | 0 | 6 | Cellular responses to stimuli; Disease; Hemostasis; Metabolism; Metabolism of proteins... |
| GNGT1 | G protein subunit gamma transducin 1 | concordant; pathway_flow | none | NaN | NaN | 0 | 14 | Cellular responses to stimuli; Disease; Hemostasis; Metabolism; Metabolism of proteins... |
| GNG3 | G protein subunit gamma 3 | concordant | none | NaN | NaN | 0 | 7 | Cellular responses to stimuli; Disease; Hemostasis; Metabolism; Metabolism of proteins... |
| GNB3 | G protein subunit beta 3 | concordant | none | NaN | NaN | 0 | 34 | Cellular responses to stimuli; Disease; Hemostasis; Metabolism; Metabolism of proteins... |
| GNAT1 | G protein subunit alpha transducin 1 | concordant; pathway_flow | none | NaN | NaN | 0 | 10 | Sensory Perception; Signal Transduction |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | concordant | oncogene | ONCOGENE | oncogene | 0 | 335 | Extracellular matrix organization |
| DBX1 | developing brain homeobox 1 | concordant | none | NaN | NaN | 0 | 4 | NaN |
| DAPL1 | death associated protein like 1 | concordant | none | NaN | NaN | 0 | 12 | NaN |
| DAPK2 | death associated protein kinase 2 | concordant | none | NaN | NaN | 0 | 64 | Programmed Cell Death |
| DAND5 | DAN domain BMP antagonist family member 5 | concordant | none | NaN | NaN | 0 | 4 | Developmental Biology |
| CYYR1 | cysteine and tyrosine rich 1 | concordant | none | NaN | NaN | 0 | 7 | NaN |
| CYBA | cytochrome b-245 alpha chain | top_attributed_cpg | none | NaN | NaN | 0 | 57 | Cellular responses to stimuli; Disease; Immune System; Signal Transduction |
| CYB5R2 | cytochrome b5 reductase 2 | concordant | none | NaN | NaN | 0 | 10 | Transport of small molecules |
| CUGBP2 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 11 | NaN |
| IGSF21 | immunoglobin superfamily member 21 | concordant | none | NaN | NaN | 0 | 2 | NaN |
| IGFBPL1 | insulin like growth factor binding protein like 1 | concordant | none | NaN | NaN | 0 | 7 | NaN |
| IFI44 | interferon induced protein 44 | concordant | none | NaN | NaN | 0 | 49 | Immune System |
| HRNBP3 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 2 | NaN |
| HOXA7 | homeobox A7 | concordant | none | NaN | NaN | 0 | 81 | NaN |
| HOOK1 | hook microtubule tethering protein 1 | concordant | none | NaN | NaN | 0 | 23 | NaN |
| HMGCL | 3-hydroxy-3-methylglutaryl-CoA lyase | top_attributed_cpg | none | NaN | NaN | 0 | 20 | Metabolism; Protein localization |
| LAMA2 | laminin subunit alpha 2 | concordant | none | NaN | NaN | 0 | 61 | Developmental Biology; Disease; Extracellular matrix organization; Signal Transduction |
| KLF14 | KLF transcription factor 14 | top_attributed_cpg | none | NaN | NaN | 0 | 36 | NaN |
| KLF11 | KLF transcription factor 11 | concordant | none | NaN | NaN | 0 | 56 | NaN |
| KIF1B | kinesin family member 1B | top_attributed_cpg | none | NaN | NaN | 0 | 56 | Hemostasis; Vesicle-mediated transport |
| KCTD14 | potassium channel tetramerization domain containing 14 | concordant | none | NaN | NaN | 0 | 3 | NaN |
| KCNIP1 | potassium voltage-gated channel interacting protein 1 | concordant; network_hub; top_attributed_cpg | none | NaN | NaN | 0 | 4 | Muscle contraction |
| KCNA5 | potassium voltage-gated channel subfamily A member 5 | concordant | none | NaN | NaN | 0 | 11 | Muscle contraction; Neuronal System |
| JAKMIP2 | janus kinase and microtubule interacting protein 2 | concordant | none | NaN | NaN | 0 | 3 | NaN |
| ITPRIP | inositol 1,4,5-trisphosphate receptor interacting protein | concordant; network_hub | none | NaN | NaN | 0 | 6 | NaN |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | concordant; network_hub | none | NaN | NaN | 0 | 33 | Metabolism of proteins |
| ISLR2 | immunoglobulin superfamily containing leucine rich repeat 2 | concordant | none | NaN | NaN | 0 | 6 | NaN |
| INPP5F | inositol polyphosphate-5-phosphatase F | concordant | none | NaN | NaN | 0 | 11 | Metabolism |
| ILVBL | NaN | concordant; network_hub | none | NaN | NaN | 0 | 0 | NaN |
| IL20RA | interleukin 20 receptor subunit alpha | concordant | none | NaN | NaN | 0 | 30 | Immune System |
| IL11RA | interleukin 11 receptor subunit alpha | concordant | none | NaN | NaN | 0 | 43 | Immune System |
| DEFA5 | defensin alpha 5 | concordant | none | NaN | NaN | 0 | 20 | Cellular responses to stimuli; Immune System |
| CSNK1G1 | casein kinase 1 gamma 1 | top_attributed_cpg | none | NaN | NaN | 0 | 7 | NaN |
| CRB1 | crumbs cell polarity complex component 1 | concordant; pathway_flow | none | NaN | NaN | 0 | 17 | NaN |
| CPLX4 | complexin 4 | concordant | none | NaN | NaN | 0 | 1 | NaN |
| COLQ | collagen like tail subunit of asymmetric acetylcholinesterase | concordant; network_hub | none | NaN | NaN | 0 | 7 | NaN |
| COL6A3 | collagen type VI alpha 3 chain | concordant | none | NaN | NaN | 0 | 180 | Developmental Biology; Extracellular matrix organization; Signal Transduction |
| COL21A1 | collagen type XXI alpha 1 chain | concordant | none | NaN | NaN | 0 | 10 | Extracellular matrix organization |
| COCH | cochlin | concordant | none | NaN | NaN | 0 | 31 | NaN |
| CNTN6 | contactin 6 | concordant | none | NaN | NaN | 0 | 15 | Developmental Biology |
| CNGA3 | cyclic nucleotide gated channel subunit alpha 3 | concordant; network_hub | none | NaN | NaN | 0 | 5 | NaN |
| CNGA1 | cyclic nucleotide gated channel subunit alpha 1 | concordant | none | NaN | NaN | 0 | 0 | Sensory Perception |
| LOC399959 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 1 | NaN |
| LIPA | lipase A, lysosomal acid type | top_attributed_cpg | none | NaN | NaN | 0 | 318 | Transport of small molecules |
| LINGO3 | leucine rich repeat and Ig domain containing 3 | top_attributed_cpg | none | NaN | NaN | 0 | 2 | NaN |
| LHX5 | LIM homeobox 5 | concordant | none | NaN | NaN | 0 | 5 | NaN |
| LGI1 | leucine rich glioma inactivated 1 | concordant | none | NaN | NaN | 0 | 127 | Developmental Biology |
| LEMD1 | LEM domain containing 1 | concordant | none | NaN | NaN | 0 | 29 | NaN |
| MAPK10 | mitogen-activated protein kinase 10 | concordant | none | NaN | NaN | 0 | 88 | Cellular responses to stimuli; Immune System |
| MAML3 | mastermind like transcriptional coactivator 3 | top_attributed_cpg | none | NaN | NaN | 0 | 82 | Developmental Biology; Disease; Gene expression (Transcription); Signal Transduction |
| MAB21L2 | mab-21 like 2 | concordant | none | NaN | NaN | 0 | 7 | NaN |
| LRTM1 | leucine rich repeat transmembrane protein 1 | concordant | none | NaN | NaN | 0 | 2 | NaN |
| LRRN4 | leucine rich repeat neuronal 4 | top_attributed_cpg | none | NaN | NaN | 0 | 7 | NaN |
| LRRC61 | leucine rich repeat containing 61 | concordant | none | NaN | NaN | 0 | 2 | NaN |
| LRRC55 | leucine rich repeat containing 55 | concordant | none | NaN | NaN | 0 | 1 | NaN |
| LRP6 | LDL receptor related protein 6 | pathway_flow | oncogene | ONCOGENE | NaN | 0 | 434 | Disease; Signal Transduction |
| LRP4 | LDL receptor related protein 4 | concordant; network_hub | none | NaN | NaN | 0 | 36 | Extracellular matrix organization |
| LRIT2 | leucine rich repeat, Ig-like and transmembrane domains 2 | top_attributed_cpg | none | NaN | NaN | 0 | 0 | NaN |
| LRIT1 | leucine rich repeat, Ig-like and transmembrane domains 1 | concordant | none | NaN | NaN | 0 | 0 | NaN |
| LRIG3 | leucine rich repeats and immunoglobulin like domains 3 | concordant | none | NaN | NaN | 0 | 41 | NaN |
| LPIN1 | lipin 1 | concordant | none | NaN | NaN | 0 | 32 | Cell Cycle; Gene expression (Transcription); Metabolism |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | top_attributed_cpg | none | NaN | NaN | 0 | 123 | Immune System; Metabolism |
| CSRNP3 | cysteine and serine rich nuclear protein 3 | concordant | none | NaN | NaN | 0 | 3 | NaN |
| CSPG4 | chondroitin sulfate proteoglycan 4 | concordant | none | NaN | NaN | 0 | 202 | Developmental Biology; Disease; Metabolism |
| CER1 | cerberus 1, DAN family BMP antagonist | concordant; network_hub | none | NaN | NaN | 0 | 22 | Developmental Biology; Signal Transduction |
| CDON | cell adhesion associated, oncogene regulated | pathway_flow | none | NaN | NaN | 0 | 19 | Developmental Biology; Signal Transduction |
| CDH12 | cadherin 12 | concordant | none | NaN | NaN | 0 | 15 | Cell-Cell communication |
| CDC42EP3 | CDC42 effector protein 3 | concordant | none | NaN | NaN | 0 | 19 | Signal Transduction |
| MPP3 | MAGUK p55 scaffold protein 3 | concordant | none | NaN | NaN | 0 | 16 | NaN |
| MIR657 | microRNA 657 | top_attributed_cpg | none | NaN | NaN | 0 | 12 | NaN |
| MIR124-2 | microRNA 124-2 | top_attributed_cpg | none | NaN | NaN | 0 | 50 | NaN |
| MICALCL | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 1 | NaN |
| MGP | matrix Gla protein | concordant | none | NaN | NaN | 0 | 194 | NaN |
| MFNG | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | concordant | none | NaN | NaN | 0 | 20 | Signal Transduction |
| MFHAS1 | multifunctional ROCO family signaling regulator 1 | concordant | none | NaN | NaN | 0 | 15 | NaN |
| MERTK | MER proto-oncogene, tyrosine kinase | top_attributed_cpg | oncogene | ONCOGENE | NaN | 0 | 369 | Disease; Hemostasis |
| ME3 | malic enzyme 3 | concordant | none | NaN | NaN | 0 | 88 | Metabolism |
| MDFIC | MyoD family inhibitor domain containing | concordant; network_hub | none | NaN | NaN | 0 | 10 | NaN |
| MCTP2 | multiple C2 and transmembrane domain containing 2 | concordant | none | NaN | NaN | 0 | 7 | NaN |
| MAPKBP1 | mitogen-activated protein kinase binding protein 1 | top_attributed_cpg | none | NaN | NaN | 0 | 1 | NaN |
| NHLH2 | nescient helix-loop-helix 2 | concordant | none | NaN | NaN | 0 | 5 | NaN |
| NEUROD4 | neuronal differentiation 4 | concordant | none | NaN | NaN | 0 | 12 | NaN |
| NAV2 | neuron navigator 2 | concordant | none | NaN | NaN | 0 | 17 | NaN |
| MYT1 | myelin transcription factor 1 | concordant | none | NaN | NaN | 0 | 81 | NaN |
| MYOT | myotilin | concordant | none | NaN | NaN | 0 | 6 | NaN |
| MYO3B | myosin IIIB | concordant | none | NaN | NaN | 0 | 3 | Sensory Perception |
| MTMR11 | myotubularin related protein 11 | concordant | none | NaN | NaN | 0 | 5 | NaN |
| MS4A4A | membrane spanning 4-domains A4A | concordant; network_hub | none | NaN | NaN | 0 | 32 | NaN |
| MPP4 | MAGUK p55 scaffold protein 4 | concordant | none | NaN | NaN | 0 | 5 | NaN |
| CLYBL | citramalyl-CoA lyase | top_attributed_cpg | none | NaN | NaN | 0 | 2 | NaN |
| CLIP3 | CAP-Gly domain containing linker protein 3 | concordant | none | NaN | NaN | 0 | 3 | Signal Transduction |
| CLIP2 | CAP-Gly domain containing linker protein 2 | concordant | none | NaN | NaN | 0 | 22 | NaN |
| CKB | creatine kinase B | concordant | none | NaN | NaN | 0 | 145 | Metabolism; Signal Transduction |
| CHRNA1 | cholinergic receptor nicotinic alpha 1 subunit | concordant | none | NaN | NaN | 0 | 7 | Neuronal System |
| CHN2 | chimerin 2 | concordant | none | NaN | NaN | 0 | 19 | Signal Transduction |
| CHI3L1 | chitinase 3 like 1 | concordant | none | NaN | NaN | 0 | 374 | Immune System |
| PCDHB15 | protocadherin beta 15 | concordant | none | NaN | NaN | 0 | 4 | NaN |
| PCDHA1 | protocadherin alpha 1 | concordant | none | NaN | NaN | 0 | 9 | NaN |
| PART1 | prostate androgen-regulated transcript 1 | concordant | none | NaN | NaN | 0 | 94 | NaN |
| PALMD | palmdelphin | concordant | none | NaN | NaN | 0 | 9 | NaN |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | concordant | none | NaN | NaN | 0 | 6 | Vesicle-mediated transport |
| OTX2OS1 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 1 | NaN |
| OSBPL1A | oxysterol binding protein like 1A | top_attributed_cpg | none | NaN | NaN | 0 | 11 | Immune System; Metabolism |
| OSBPL10 | oxysterol binding protein like 10 | concordant | none | NaN | NaN | 0 | 19 | Metabolism |
| ONECUT1 | one cut homeobox 1 | concordant | none | NaN | NaN | 0 | 21 | Developmental Biology |
| NTN5 | netrin 5 | concordant | none | NaN | NaN | 0 | 5 | NaN |
| NRIP2 | nuclear receptor interacting protein 2 | concordant | none | NaN | NaN | 0 | 3 | NaN |
| NR2E3 | nuclear receptor subfamily 2 group E member 3 | concordant; pathway_flow | none | NaN | NaN | 0 | 16 | Gene expression (Transcription) |
| NOTUM | notum, palmitoleoyl-protein carboxylesterase | pathway_flow | none | NaN | NaN | 0 | 53 | Metabolism of proteins; Signal Transduction |
| NOD2 | nucleotide binding oligomerization domain containing 2 | concordant | none | NaN | NaN | 0 | 550 | Disease; Immune System; Metabolism of proteins |
| NKX6-1 | NK6 homeobox 1 | top_attributed_cpg | none | NaN | NaN | 0 | 50 | Developmental Biology |
| NID2 | nidogen 2 | concordant | none | NaN | NaN | 0 | 64 | Extracellular matrix organization |
| PLCD4 | phospholipase C delta 4 | concordant | none | NaN | NaN | 0 | 6 | Metabolism |
| PIRT | phosphoinositide interacting regulator of transient receptor potential channels | concordant | none | NaN | NaN | 0 | 12 | NaN |
| PHYHD1 | phytanoyl-CoA dioxygenase domain containing 1 | concordant | none | NaN | NaN | 0 | 9 | NaN |
| PFDN1 | prefoldin subunit 1 | top_attributed_cpg | none | NaN | NaN | 0 | 14 | Metabolism of proteins |
| PDZD2 | PDZ domain containing 2 | top_attributed_cpg | none | NaN | NaN | 0 | 13 | NaN |
| PDPN | podoplanin | concordant | none | NaN | NaN | 0 | 346 | Hemostasis; Reproduction |
| PDLIM4 | PDZ and LIM domain 4 | concordant; network_hub | none | NaN | NaN | 0 | 39 | NaN |
| PDE7B | phosphodiesterase 7B | concordant | none | NaN | NaN | 0 | 18 | Signal Transduction |
| PDE6H | phosphodiesterase 6H | concordant; pathway_flow | none | NaN | NaN | 0 | 4 | NaN |
| PDE6B | phosphodiesterase 6B | pathway_flow | none | NaN | NaN | 0 | 6 | Sensory Perception; Signal Transduction |
| PDE1A | phosphodiesterase 1A | concordant | none | NaN | NaN | 0 | 15 | Hemostasis; Signal Transduction |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | concordant | none | NaN | NaN | 0 | 36 | Metabolism of proteins |
| PCOLCE | procollagen C-endopeptidase enhancer | concordant | none | NaN | NaN | 0 | 31 | Extracellular matrix organization |
| PCDHGB5 | protocadherin gamma subfamily B, 5 | top_attributed_cpg | none | NaN | NaN | 0 | 1 | NaN |
| PCDHB7 | protocadherin beta 7 | concordant | none | NaN | NaN | 0 | 3 | NaN |
| PCDHB3 | protocadherin beta 3 | concordant | none | NaN | NaN | 0 | 2 | NaN |
| CAMKK1 | calcium/calmodulin dependent protein kinase kinase 1 | concordant | none | NaN | NaN | 0 | 11 | Neuronal System; Signal Transduction |
| CALHM2 | calcium homeostasis modulator family member 2 | concordant | none | NaN | NaN | 0 | 5 | NaN |
| CADM3 | cell adhesion molecule 3 | top_attributed_cpg | none | NaN | NaN | 0 | 22 | Cell-Cell communication |
| CACNG5 | calcium voltage-gated channel auxiliary subunit gamma 5 | concordant | none | NaN | NaN | 0 | 1 | NaN |
| CACNA2D4 | calcium voltage-gated channel auxiliary subunit alpha2delta 4 | concordant | none | NaN | NaN | 0 | 6 | NaN |
| CACNA2D2 | calcium voltage-gated channel auxiliary subunit alpha2delta 2 | top_attributed_cpg | none | NaN | NaN | 0 | 42 | Metabolism; Muscle contraction; Neuronal System; Sensory Perception |
| CACNA1S | calcium voltage-gated channel subunit alpha1 S | concordant | none | NaN | NaN | 0 | 12 | Developmental Biology |
| CACNA1E | calcium voltage-gated channel subunit alpha1 E | concordant | none | NaN | NaN | 0 | 20 | Metabolism; Neuronal System |
| CACNA1A | calcium voltage-gated channel subunit alpha1 A | concordant; top_attributed_cpg | none | NaN | NaN | 0 | 28 | Metabolism; Neuronal System |
| POU6F2 | POU class 6 homeobox 2 | concordant | none | NaN | NaN | 0 | 25 | NaN |
| POU2F1 | POU class 2 homeobox 1 | top_attributed_cpg | none | NaN | NaN | 0 | 85 | Developmental Biology; Gene expression (Transcription); Immune System; Signal Transduc... |
| POSTN | periostin | concordant | none | NaN | NaN | 0 | 467 | NaN |
| PLIN3 | perilipin 3 | concordant | none | NaN | NaN | 0 | 41 | Autophagy; Metabolism; Signal Transduction; Vesicle-mediated transport |
| PLEKHF2 | pleckstrin homology and FYVE domain containing 2 | concordant | none | NaN | NaN | 0 | 2 | NaN |
| PLEKHB1 | pleckstrin homology domain containing B1 | top_attributed_cpg | none | NaN | NaN | 0 | 3 | NaN |
| PLCH1 | phospholipase C eta 1 | concordant | none | NaN | NaN | 0 | 9 | Metabolism |
| RANBP17 | RAN binding protein 17 | concordant | none | NaN | NaN | 0 | 6 | NaN |
| RAB34 | RAB34, member RAS oncogene family | concordant | none | NaN | NaN | 0 | 21 | Metabolism of proteins |
| QPRT | quinolinate phosphoribosyltransferase | concordant | none | NaN | NaN | 0 | 33 | Metabolism |
| QPCT | glutaminyl-peptide cyclotransferase | concordant | none | NaN | NaN | 0 | 29 | Immune System |
| PTP4A1 | protein tyrosine phosphatase 4A1 | concordant | none | INSUFFICIENT_EVIDENCE | NaN | 0 | 46 | NaN |
| PTK2B | protein tyrosine kinase 2 beta | top_attributed_cpg | none | NaN | NaN | 0 | 49 | Cell-Cell communication; Immune System; Signal Transduction |
| PTCHD2 | NaN | concordant | none | NaN | NaN | 0 | 7 | NaN |
| PRPH2 | peripherin 2 | concordant; pathway_flow | none | NaN | NaN | 0 | 4 | NaN |
| PRNP | prion protein (Kanno blood group) | concordant | none | NaN | NaN | 0 | 95 | Developmental Biology; Protein localization |
| PRKCQ | protein kinase C theta | top_attributed_cpg | none | NaN | NaN | 0 | 59 | Developmental Biology; Gene expression (Transcription); Hemostasis; Immune System; Pro... |
| PRKAR1B | protein kinase cAMP-dependent type I regulatory subunit beta | top_attributed_cpg | none | NaN | NaN | 0 | 16 | Cellular responses to stimuli; Disease; Hemostasis; Metabolism; Neuronal System; Signa... |
| PRELID2 | PRELI domain containing 2 | concordant | none | NaN | NaN | 0 | 6 | NaN |
| CCDC8 | coiled-coil domain containing 8 subunit of 3M complex | concordant | none | NaN | NaN | 0 | 17 | Metabolism of proteins |
| CCDC36 | NaN | concordant | none | NaN | NaN | 0 | 3 | NaN |
| CASZ1 | castor zinc finger 1 | top_attributed_cpg | none | NaN | NaN | 0 | 39 | NaN |
| CAPS | calcyphosine | concordant | none | NaN | NaN | 0 | 739 | NaN |
| SASH1 | SAM and SH3 domain containing 1 | top_attributed_cpg | none | NaN | NaN | 0 | 94 | NaN |
| SAMD3 | sterile alpha motif domain containing 3 | concordant | none | NaN | NaN | 0 | 12 | NaN |
| RPTOR | regulatory associated protein of MTOR complex 1 | top_attributed_cpg | oncogene | ONCOGENE | NaN | 0 | 78 | Autophagy; Cellular responses to stimuli; Disease; Gene expression (Transcription); Si... |
| ROM1 | retinal outer segment membrane protein 1 | pathway_flow | none | NaN | NaN | 0 | 4 | NaN |
| RNF212 | ring finger protein 212 | concordant | none | NaN | NaN | 0 | 7 | NaN |
| RNF112 | ring finger protein 112 | concordant; top_attributed_cpg | none | NaN | NaN | 0 | 8 | NaN |
| RIMS2 | regulating synaptic membrane exocytosis 2 | top_attributed_cpg | none | NaN | NaN | 0 | 18 | NaN |
| RHOJ | ras homolog family member J | concordant | none | NaN | NaN | 0 | 47 | Signal Transduction |
| REG1B | regenerating family member 1 beta | concordant | none | NaN | NaN | 0 | 20 | NaN |
| RDH12 | retinol dehydrogenase 12 | top_attributed_cpg | none | NaN | NaN | 0 | 11 | Disease; Sensory Perception |
| RD3 | RD3 regulator of GUCY2D | concordant | none | NaN | NaN | 0 | 20 | NaN |
| RASSF9 | Ras association domain family member 9 | concordant | none | NaN | NaN | 0 | 12 | NaN |
| RASSF3 | Ras association domain family member 3 | concordant | none | NaN | NaN | 0 | 19 | NaN |
| RASIP1 | Ras interacting protein 1 | concordant | none | NaN | NaN | 0 | 8 | NaN |
| RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2 | concordant | none | NaN | NaN | 0 | 29 | Neuronal System; Signal Transduction |
| RASGEF1C | RasGEF domain family member 1C | concordant | none | NaN | NaN | 0 | 3 | NaN |
| SLC14A1 | solute carrier family 14 member 1 (Kidd blood group) | concordant | none | NaN | NaN | 0 | 43 | Transport of small molecules |
| SLC13A3 | solute carrier family 13 member 3 | concordant | none | NaN | NaN | 0 | 9 | Transport of small molecules |
| SLAIN1 | SLAIN family member 1 | top_attributed_cpg | none | NaN | NaN | 0 | 7 | NaN |
| SH3D19 | SH3 domain containing 19 | concordant | none | NaN | NaN | 0 | 1 | Vesicle-mediated transport |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | concordant | none | NaN | NaN | 0 | 20 | Metabolism |
| SGIP1 | SH3GL interacting endocytic adaptor 1 | concordant | none | NaN | NaN | 0 | 8 | Vesicle-mediated transport |
| SFN | stratifin | concordant | none | NaN | NaN | 0 | 941 | Cell Cycle; Disease; Gene expression (Transcription); Immune System; Programmed Cell D... |
| SERTAD4 | SERTA domain containing 4 | concordant | none | NaN | NaN | 0 | 5 | NaN |
| SERPINF1 | serpin family F member 1 | concordant | none | NaN | NaN | 0 | 49 | NaN |
| SERPIND1 | serpin family D member 1 | concordant | none | NaN | NaN | 0 | 18 | Hemostasis; Metabolism of proteins |
| SERP2 | stress associated endoplasmic reticulum protein family member 2 | concordant | none | NaN | NaN | 0 | 6 | NaN |
| SEPP1 | NaN | concordant | none | NaN | NaN | 0 | 73 | NaN |
| SEMA6A | semaphorin 6A | concordant; network_hub | none | NaN | NaN | 0 | 44 | Developmental Biology |
| SELENBP1 | selenium binding protein 1 | concordant | none | NaN | NaN | 0 | 73 | NaN |
| SDK1 | sidekick cell adhesion molecule 1 | top_attributed_cpg | none | NaN | NaN | 0 | 19 | Cell-Cell communication |
| SCG5 | secretogranin V | concordant | oncogene | ONCOGENE | NaN | 0 | 25 | NaN |
| C7orf58 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 0 | NaN |
| C7orf33 | chromosome 7 open reading frame 33 | concordant; network_hub | none | NaN | NaN | 0 | 0 | NaN |
| C6orf123 | NaN | concordant; network_hub | none | NaN | NaN | 0 | 0 | NaN |
| C2orf71 | NaN | concordant | none | NaN | NaN | 0 | 2 | NaN |
| C21orf34 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 1 | NaN |
| C1orf61 | NaN | concordant | none | NaN | NaN | 0 | 4 | NaN |
| C14orf39 | chromosome 14 open reading frame 39 | concordant | none | NaN | NaN | 0 | 1 | NaN |
| C14orf23 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 1 | NaN |
| BTBD11 | NaN | concordant | none | NaN | NaN | 0 | 2 | NaN |
| BMP5 | bone morphogenetic protein 5 | concordant | none | NaN | NaN | 0 | 71 | NaN |
| BCHE | butyrylcholinesterase | concordant | none | NaN | NaN | 0 | 243 | Drug ADME; Metabolism; Metabolism of proteins; Neuronal System |
| SLC20A2 | solute carrier family 20 member 2 | concordant; top_attributed_cpg | none | NaN | NaN | 0 | 8 | Disease; Transport of small molecules |
| SLC1A7 | solute carrier family 1 member 7 | concordant | none | NaN | NaN | 0 | 4 | Neuronal System; Transport of small molecules |
| SLC1A4 | solute carrier family 1 member 4 | concordant | none | NaN | NaN | 0 | 27 | Transport of small molecules |
| SLC17A6 | solute carrier family 17 member 6 | concordant | none | NaN | NaN | 0 | 5 | Transport of small molecules |
| SLC16A4 | solute carrier family 16 member 4 | concordant | none | NaN | NaN | 0 | 18 | NaN |
| SPINK5 | serine peptidase inhibitor Kazal type 5 | concordant | none | NaN | NaN | 0 | 53 | Developmental Biology |
| SPAG6 | sperm associated antigen 6 | concordant | none | NaN | NaN | 0 | 35 | NaN |
| SP6 | Sp6 transcription factor | top_attributed_cpg | none | NaN | NaN | 0 | 152 | NaN |
| SP5 | Sp5 transcription factor | concordant; pathway_flow | none | NaN | NaN | 0 | 64 | NaN |
| SOSTDC1 | sclerostin domain containing 1 | concordant | none | NaN | NaN | 0 | 41 | NaN |
| SLCO4C1 | solute carrier organic anion transporter family member 4C1 | concordant | none | NaN | NaN | 0 | 11 | Immune System; Transport of small molecules |
| SLC6A5 | solute carrier family 6 member 5 | concordant | none | NaN | NaN | 0 | 3 | Disease; Transport of small molecules |
| SLC6A3 | solute carrier family 6 member 3 | concordant | none | NaN | NaN | 0 | 41 | NaN |
| SLC4A10 | solute carrier family 4 member 10 | concordant | none | NaN | NaN | 0 | 6 | Transport of small molecules |
| SLC38A1 | solute carrier family 38 member 1 | concordant | none | NaN | NaN | 0 | 60 | Neuronal System; Transport of small molecules |
| SLC35D2 | solute carrier family 35 member D2 | concordant | none | NaN | NaN | 0 | 3 | Metabolism; Transport of small molecules |
| SLC2A1 | solute carrier family 2 member 1 | top_attributed_cpg | none | NaN | NaN | 0 | 400 | Disease; Metabolism; Transport of small molecules |
| CABP1 | calcium binding protein 1 | top_attributed_cpg | none | NaN | NaN | 0 | 7 | Sensory Perception |
| CA14 | carbonic anhydrase 14 | concordant | none | NaN | NaN | 0 | 14 | Metabolism |
| C9orf3 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 7 | NaN |
| C8orf46 | NaN | concordant | none | NaN | NaN | 0 | 3 | NaN |
| THBS4 | thrombospondin 4 | concordant | none | NaN | NaN | 0 | 58 | Signal Transduction |
| TGFB3 | transforming growth factor beta 3 | concordant | none | NaN | NaN | 0 | 89 | Extracellular matrix organization; Hemostasis; Signal Transduction |
| TFCP2 | transcription factor CP2 | concordant | none | NaN | NaN | 0 | 87 | NaN |
| TESK2 | testis associated actin remodelling kinase 2 | concordant | none | NaN | NaN | 0 | 3 | NaN |
| TCF7L2 | transcription factor 7 like 2 | pathway_flow | both | TSG | fusion; oncogene | 0 | 360 | Developmental Biology; Disease; Gene expression (Transcription); Immune System; Metabo... |
| TCF7 | transcription factor 7 | pathway_flow | none | NaN | NaN | 0 | 260 | Developmental Biology; Gene expression (Transcription); Immune System; Signal Transduc... |
| TBX18 | T-box transcription factor 18 | concordant | none | NaN | NaN | 0 | 16 | NaN |
| TBC1D9 | TBC1 domain family member 9 | top_attributed_cpg | none | NaN | NaN | 0 | 12 | NaN |
| TAC1 | tachykinin precursor 1 | concordant | none | NaN | NaN | 0 | 79 | Signal Transduction |
| SYT4 | synaptotagmin 4 | concordant | none | NaN | NaN | 0 | 10 | NaN |
| SYCP2L | synaptonemal complex protein 2 like | concordant | none | NaN | NaN | 0 | 3 | NaN |
| SULT1C4 | sulfotransferase family 1C member 4 | concordant | none | NaN | NaN | 0 | 5 | Drug ADME; Metabolism |
| STRA6 | signaling receptor and transporter of retinol STRA6 | concordant | none | NaN | NaN | 0 | 44 | NaN |
| SRP68 | signal recognition particle 68 | top_attributed_cpg | none | NaN | NaN | 0 | 5 | Metabolism of proteins |
| SRL | sarcalumenin | concordant | none | NaN | NaN | 0 | 229 | NaN |
| SPTLC3 | serine palmitoyltransferase long chain base subunit 3 | top_attributed_cpg | none | NaN | NaN | 0 | 6 | Metabolism |
| ZNF334 | zinc finger protein 334 | concordant | none | NaN | NaN | 0 | 8 | Gene expression (Transcription) |
| ALDH5A1 | aldehyde dehydrogenase 5 family member A1 | concordant | none | NaN | NaN | 0 | 20 | Neuronal System |
| AKR1E2 | aldo-keto reductase family 1 member E2 | concordant | none | NaN | NaN | 0 | 3 | Metabolism |
| AKAP6 | A-kinase anchoring protein 6 | concordant; network_hub | none | NaN | NaN | 0 | 8 | NaN |
| AIPL1 | AIP like 1 HSP90 co-chaperone | concordant; pathway_flow; top_attributed_cpg | none | NaN | NaN | 0 | 3 | NaN |
| AHNAK | AHNAK nucleoprotein | concordant | none | NaN | NaN | 0 | 143 | NaN |
| AFF3 | ALF transcription elongation factor 3 | concordant | none | NaN | NaN | 0 | 33 | NaN |
| ADAM19 | ADAM metallopeptidase domain 19 | concordant | none | NaN | NaN | 0 | 46 | Cell-Cell communication; Extracellular matrix organization |
| ACSS3 | acyl-CoA synthetase short chain family member 3 | concordant | none | NaN | NaN | 0 | 21 | Gene expression (Transcription); Metabolism |
| ACPP | NaN | concordant | none | NaN | NaN | 0 | 101 | NaN |
| ACACA | acetyl-CoA carboxylase alpha | top_attributed_cpg | oncogene | ONCOGENE | NaN | 0 | 127 | Disease; Metabolism |
| ABCA9 | ATP binding cassette subfamily A member 9 | concordant | none | NaN | NaN | 0 | 17 | Transport of small molecules |
| ABCA4 | ATP binding cassette subfamily A member 4 | concordant | none | NaN | NaN | 0 | 14 | Disease; Sensory Perception; Transport of small molecules |
| BAHCC1 | BAH domain and coiled-coil containing 1 | top_attributed_cpg | none | NaN | NaN | 0 | 7 | NaN |
| ATP8A2 | ATPase phospholipid transporting 8A2 | top_attributed_cpg | none | NaN | NaN | 0 | 13 | Transport of small molecules |
| ATP5G2 | NaN | top_attributed_cpg | none | NaN | NaN | 0 | 6 | NaN |
| EMB | embigin | concordant | none | NaN | NaN | 0 | 123 | Transport of small molecules |
| VWA5A | von Willebrand factor A domain containing 5A | concordant | none | NaN | NaN | 0 | 8 | NaN |
| VRK2 | VRK serine/threonine kinase 2 | concordant; top_attributed_cpg | none | NaN | NaN | 0 | 38 | Cell Cycle; Signal Transduction |
| VPS37B | VPS37B subunit of ESCRT-I | top_attributed_cpg | none | NaN | NaN | 0 | 4 | Autophagy; Disease; Vesicle-mediated transport |
| UGT2A3 | UDP glucuronosyltransferase family 2 member A3 | top_attributed_cpg | none | NaN | NaN | 0 | 12 | Drug ADME; Metabolism |
| TXNDC12 | thioredoxin domain containing 12 | top_attributed_cpg | none | NaN | NaN | 0 | 17 | NaN |
| TSPYL5 | TSPY like 5 | concordant | none | NaN | NaN | 0 | 44 | NaN |
| TSPAN9 | tetraspanin 9 | concordant | none | NaN | NaN | 0 | 18 | NaN |
| TSPAN5 | tetraspanin 5 | concordant | none | NaN | NaN | 0 | 23 | Metabolism of proteins |
| TRPS1 | transcriptional repressor GATA binding 1 | concordant | none | NaN | NaN | 0 | 215 | NaN |
| TRPM3 | transient receptor potential cation channel subfamily M member 3 | concordant | none | NaN | NaN | 0 | 53 | Transport of small molecules |
| TRIP10 | thyroid hormone receptor interactor 10 | concordant | none | NaN | NaN | 0 | 9 | Signal Transduction; Vesicle-mediated transport |
| TRAF3IP2 | TRAF3 interacting protein 2 | concordant | none | NaN | NaN | 0 | 43 | NaN |
| ZSCAN12 | zinc finger and SCAN domain containing 12 | concordant | none | NaN | NaN | 0 | 12 | NaN |
| ZNF681 | zinc finger protein 681 | concordant | none | NaN | NaN | 0 | 1 | Gene expression (Transcription) |
| ZNF418 | zinc finger protein 418 | concordant | none | NaN | NaN | 0 | 7 | Gene expression (Transcription) |
Page 8 of 9. previous: 7. Gene clusters and pathway flow | index | next: 9. Conclusions