/* DrugInteract styles. Light/dark via prefers-color-scheme. */

:root {
  --bg: #f6f7f9;
  --surface: #ffffff;
  --surface-2: #f0f2f5;
  --text: #1c2128;
  --text-muted: #57606a;
  --border: #d8dee4;
  --accent: #0b66c3;
  --accent-text: #ffffff;

  /* result-state accents (color is paired with a text label, never color-only) */
  --state-mention: #b42318;     /* interaction text found in a label */
  --state-mention-bg: #fdecea;
  --state-nomention: #3a4a5a;   /* checked, nothing found - NEUTRAL, never green */
  --state-nomention-bg: #eef1f4;
  --state-nolabel: #6b4fbb;     /* recognized but no label to check */
  --state-nolabel-bg: #f0ecfa;
  --state-unrecognized: #9a6700; /* not recognized by RxNorm */
  --state-unrecognized-bg: #fdf3df;
  --state-ratelimit: #c2410c;    /* API rate limit (HTTP 429) */
  --state-ratelimit-bg: #fde7d6;
  --state-error: #57606a;
  --state-error-bg: #f0f2f5;

  --radius: 10px;
  --maxw: 880px;
  --font: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Helvetica, Arial, sans-serif;
}

@media (prefers-color-scheme: dark) {
  :root {
    --bg: #0d1117;
    --surface: #161b22;
    --surface-2: #1c2330;
    --text: #e6edf3;
    --text-muted: #9198a1;
    --border: #2d333b;
    --accent: #4493f8;
    --accent-text: #0d1117;
    --state-mention: #ff7b72;     --state-mention-bg: #2a1715;
    --state-nomention: #adbac7;   --state-nomention-bg: #1b2230;
    --state-nolabel: #b29df0;     --state-nolabel-bg: #1f1a2e;
    --state-unrecognized: #e3b341; --state-unrecognized-bg: #251f10;
    --state-ratelimit: #ff9e6d;    --state-ratelimit-bg: #2a1a10;
    --state-error: #9198a1;        --state-error-bg: #1c2330;
  }
}

* { box-sizing: border-box; }

body {
  margin: 0;
  font-family: var(--font);
  color: var(--text);
  background: var(--bg);
  line-height: 1.5;
  -webkit-text-size-adjust: 100%;
}

a { color: var(--accent); }

.wrap { max-width: var(--maxw); margin: 0 auto; padding: 0 16px; }

/* Header */
.site-header { background: var(--surface); border-bottom: 1px solid var(--border); }
.site-header .wrap { display: flex; align-items: baseline; justify-content: space-between; gap: 12px; padding-top: 18px; padding-bottom: 18px; flex-wrap: wrap; }
.brand { font-size: 1.5rem; font-weight: 700; letter-spacing: -0.01em; }
.brand small { display: block; font-size: 0.82rem; font-weight: 400; color: var(--text-muted); letter-spacing: 0; }
.nav a { margin-left: 16px; text-decoration: none; font-weight: 500; }
.nav a:hover { text-decoration: underline; }

/* Disclaimer banner */
.disclaimer {
  background: var(--state-unrecognized-bg);
  border-bottom: 1px solid var(--border);
  color: var(--text);
}
.disclaimer .wrap { padding-top: 12px; padding-bottom: 12px; font-size: 0.9rem; }
.disclaimer strong { color: var(--state-unrecognized); }

main { padding: 24px 0 48px; }

.card {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  padding: 20px;
  margin-bottom: 20px;
}

h1, h2, h3 { line-height: 1.25; }
.lead { color: var(--text-muted); margin-top: 0; }

/* Input rows */
.drug-rows { display: flex; flex-direction: column; gap: 10px; margin: 14px 0; }
.drug-row { display: flex; gap: 8px; align-items: center; }
.drug-row .idx { width: 1.6rem; color: var(--text-muted); font-variant-numeric: tabular-nums; text-align: right; }
.drug-row input[type="text"] {
  flex: 1;
  padding: 10px 12px;
  font-size: 1rem;
  color: var(--text);
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 8px;
}
.drug-row input:focus { outline: 2px solid var(--accent); outline-offset: 1px; border-color: var(--accent); }

/* Autocomplete dropdown */
.ac-wrap { position: relative; flex: 1; }
.ac-wrap:focus-within { z-index: 40; }
.ac-wrap input[type="text"] { width: 100%; }
.ac-list {
  position: absolute;
  top: calc(100% + 2px);
  left: 0;
  right: 0;
  z-index: 30;
  margin: 0;
  padding: 4px 0;
  list-style: none;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 8px;
  max-height: 260px;
  overflow-y: auto;
  box-shadow: 0 6px 20px rgba(0, 0, 0, 0.16);
}
.ac-item {
  padding: 8px 12px;
  cursor: pointer;
  font-size: 0.95rem;
  white-space: nowrap;
  overflow: hidden;
  text-overflow: ellipsis;
}
.ac-item:hover, .ac-item.active { background: var(--surface-2); }

button {
  font: inherit;
  cursor: pointer;
  border-radius: 8px;
  border: 1px solid var(--border);
  background: var(--surface-2);
  color: var(--text);
  padding: 9px 14px;
}
button:hover { border-color: var(--accent); }
button:focus-visible { outline: 2px solid var(--accent); outline-offset: 1px; }
.btn-icon { padding: 9px 12px; line-height: 1; }
.btn-primary { background: var(--accent); color: var(--accent-text); border-color: var(--accent); font-weight: 600; }
.btn-primary:disabled { opacity: 0.55; cursor: progress; }
.controls { display: flex; gap: 10px; flex-wrap: wrap; margin-top: 8px; }

.hint { color: var(--text-muted); font-size: 0.88rem; }

/* Example chips */
.examples { display: flex; align-items: center; gap: 8px 10px; flex-wrap: wrap; margin-top: 12px; }
.example-chips { display: inline-flex; gap: 8px; flex-wrap: wrap; }
.chip {
  font-size: 0.86rem;
  padding: 5px 12px;
  border-radius: 999px;
  background: var(--surface-2);
  border: 1px solid var(--border);
  color: var(--text);
  cursor: pointer;
}
.chip:hover { border-color: var(--accent); }

/* Inline note (e.g. pairwise-only caveat near results) */
.note { font-size: 0.9rem; color: var(--text-muted); margin: 0 0 14px; }

/* Drug profiles (RxClass) - informational, visually separate from findings */
.card.profiles { border-style: dashed; }
.profile { padding: 12px 0; border-top: 1px solid var(--border); }
.profile:first-of-type { border-top: none; }
.profile h3 { margin: 0 0 8px; font-size: 1rem; }
.profile-body { display: flex; flex-direction: column; gap: 6px; }
.profile-row { display: flex; gap: 10px; flex-wrap: wrap; font-size: 0.92rem; }
.profile-label { flex: 0 0 200px; color: var(--text-muted); }
.profile-value { flex: 1; min-width: 200px; }
.profile-value.cyp { display: flex; flex-direction: column; gap: 3px; }
.cyp-tag {
  display: inline-block;
  min-width: 74px;
  font-size: 0.74rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.03em;
  color: var(--text-muted);
}
@media (max-width: 560px) {
  .profile-label { flex-basis: 100%; }
}

/* Status / spinner */
.status { margin: 14px 0; color: var(--text-muted); min-height: 1.2em; }

/* Per-drug normalization summary */
.drug-summary { margin: 8px 0 4px; }
.drug-summary ul { list-style: none; padding: 0; margin: 8px 0 0; display: flex; flex-direction: column; gap: 6px; }
.drug-summary li { font-size: 0.9rem; padding: 8px 10px; background: var(--surface-2); border-radius: 8px; }
.drug-summary .name-in { font-weight: 600; }
.tag { display: inline-block; font-size: 0.78rem; padding: 1px 7px; border-radius: 999px; border: 1px solid var(--border); color: var(--text-muted); margin-left: 6px; }

/* Results */
.pair {
  border: 1px solid var(--border);
  border-left-width: 6px;
  border-radius: var(--radius);
  padding: 14px 16px;
  margin-bottom: 14px;
  background: var(--surface);
}
.pair h3 { margin: 0 0 6px; font-size: 1.05rem; }
.badge {
  display: inline-block;
  font-size: 0.76rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.03em;
  padding: 2px 8px;
  border-radius: 6px;
  vertical-align: middle;
  margin-left: 8px;
}

.pair.s-mention { border-left-color: var(--state-mention); }
.pair.s-mention .badge { background: var(--state-mention-bg); color: var(--state-mention); }
.pair.s-nomention { border-left-color: var(--state-nomention); }
.pair.s-nomention .badge { background: var(--state-nomention-bg); color: var(--state-nomention); }
.pair.s-nolabel { border-left-color: var(--state-nolabel); }
.pair.s-nolabel .badge { background: var(--state-nolabel-bg); color: var(--state-nolabel); }
.pair.s-unrecognized { border-left-color: var(--state-unrecognized); }
.pair.s-unrecognized .badge { background: var(--state-unrecognized-bg); color: var(--state-unrecognized); }
.pair.s-ratelimit { border-left-color: var(--state-ratelimit); }
.pair.s-ratelimit .badge { background: var(--state-ratelimit-bg); color: var(--state-ratelimit); }
.pair.s-error { border-left-color: var(--state-error); }
.pair.s-error .badge { background: var(--state-error-bg); color: var(--state-error); }

.finding { margin: 10px 0; padding: 10px 12px; background: var(--surface-2); border-radius: 8px; }
.finding .dir { font-weight: 600; font-size: 0.92rem; }
.finding .meta { color: var(--text-muted); font-size: 0.82rem; margin-top: 2px; }
.finding.secondary { border: 1px dashed var(--border); background: transparent; }
.finding .sec-tag { font-size: 0.72rem; font-weight: 700; text-transform: uppercase; letter-spacing: 0.03em; color: var(--text-muted); }

.snippet { margin: 8px 0 0; font-size: 0.92rem; }
.snippet mark { background: var(--state-unrecognized-bg); color: inherit; padding: 0 2px; border-radius: 3px; font-weight: 700; }
details.full { margin-top: 8px; }
details.full summary { cursor: pointer; color: var(--accent); font-size: 0.88rem; }
details.full pre { white-space: pre-wrap; word-wrap: break-word; font-size: 0.85rem; background: var(--surface-2); padding: 10px; border-radius: 8px; max-height: 320px; overflow: auto; margin-top: 8px; }

.caveat { font-size: 0.88rem; color: var(--text-muted); margin: 8px 0 0; }
.suggestions { margin-top: 8px; }
.suggestions button { font-size: 0.86rem; padding: 4px 10px; margin: 2px 6px 2px 0; }

ul.didyoumean { margin: 6px 0 0; }

/* Methods page */
.prose h2 { margin-top: 28px; }
.prose ul { padding-left: 20px; }
.prose li { margin: 6px 0; }
.prose code { background: var(--surface-2); padding: 1px 5px; border-radius: 5px; font-size: 0.9em; }

/* Footer */
.site-footer { border-top: 1px solid var(--border); background: var(--surface); color: var(--text-muted); font-size: 0.85rem; }
.site-footer .wrap { padding: 18px 16px 28px; }
.site-footer p { margin: 6px 0; }
.visually-hidden { position: absolute; width: 1px; height: 1px; overflow: hidden; clip: rect(0 0 0 0); }